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Deep vein thrombosis (DVT) most commonly occurs in the lower extremities, particularly in the deep veins of the legs, such as the femoral and popliteal veins. The risk factors for DVT, including immobility, prolonged sitting, and certain medical conditions, primarily affect the lower limbs where blood flow may be slowed or obstructed.

When considering the anatomy and physiology, the lower extremities are more prone to venous stasis due to gravitational effects, particularly when a person is immobile or sedentary. In contrast, while DVT can theoretically occur in other sites like the upper extremities or pelvis, such occurrences are far less common. The abdomen and neck are not typical sites for DVT formation; rather, they are associated with other complications or conditions. Recognizing the typical presentation of DVT is essential for early detection and prevention of complications such as pulmonary embolism.

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